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KMID : 0861020030180010001
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Korea Journal of Herbology
2003 Volume.18 No. 1 p.1 ~ p.6
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Effect of Alli Macrostemi Bulbus on Cultured Myocardial Cells Damaged by FeSO4
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Abstract
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Objectives : To clarify the myocardial toxicity of FeSO_4 in cultured rat myocardial cells, toxic effect was measured by MTT assay.
Methods : Myocardial cells were incubated for 12hours in the media containing 10~80㎛ concentrations of FeSO_4. And also, the protective effect of Alli Macrostemi Bulbus(AMB) was measured in these cultures.
Results : Cell viability was remarkably decreased in a dose- and time-dependent manners when cultured myocardial cells were exposed to 40 ㎛ FeSO_4 for 12hours. In the cytoprotective effect of AMB on FeSO_4-induced cytotoxicity, AMB blocked the FeSO_4-induced myotoxicity in these cultures.
Conclusions : From the above results, it is suggested that FeSO_4 is toxic on cultured rat myocardial cells and AMB is effective in the prevention of FeSO_4-induced myocardial toxicity.
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KEYWORD
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